Project Description

Name: Patrizia Agostinis

Current Position and Address:

Full Professor,
PI of the Cell death Research & Therapy lab, Department Cellular & Molecular Medicine
Faculty of Medicine, Campus Gasthuisberg
KU Leuven
Herestraat 49, Bus 901
B3000 Leuven, Belgium
Tel: +32.16.330650

Contact Email:

Background Career Information:

PA received her master in Biology at the University of Padova (Italy) and her PhD in biomedical science at the KU Leuven, Belgium, where she became first Research Associate of the Flemish Research Council (FWO) and then Professor at the KU Leuven. Since 2000 PA is the group leader of the Cell Death Research & Therapy lab, at the Department of Cellular & Molecular Medicine of the KU Leuven, and in 2008 she became Full Professor at the same Institution. PA’s lab has extensive expertise in research on the cell death mechanisms induced by oxidative stress and the role of cancer cell’s stress pathways, with particular emphasis on ER stress and autophagy, during tumourigenesis and in response to therapy (contributed to these fields by authoring more than 160 articles, h index 47).

PA is a member of the Board of Directors of the European Cell Death Society (ECDO) and of the International Cell Death Society (ICDS, New York), the two major societies in the field of cell death. PA team (CDRT) is one of the leading group investigating the molecular mechanisms of ER stress based and therapy-induced immunogenic cancer cell death, and contributed to define the in vivo impact of the inhibition of autophagy on the tumor microenvironment.

Research Interests:

Biological function of the ER stress sensor PERK, interorganellar contact sites, vesicular trafficking and autophagy, the immunological impact of cancer cell death, mechanisms of DAMP emission and stimulation of antitumor immunity by clinically used chemotherapeutics; identification of new immunomodulators released by dying cancer cells and their potential as biomarkers.