TRAIN-ERS Objectives

Much effort has been invested in studying the ER stress response in recent years, and while the basic pathway has been worked out there is a serious gap in our understanding of the molecular complexity of this pathway and its interactions. This includes a functional understanding of how it determines cell fate, how it is regulated within the interconnective context with other processes and stress response pathways and how it is deregulated in disease.

This lack of knowledge hinders efforts to exploit the ER stress response for therapeutic and diagnostic purposes. TRAIN-ERS will drive understanding of the ER stress response in normal and disease conditions, and this knowledge, coupled with our current understanding, will serve as a platform for drug discovery and diagnostics efforts that aim to therapeutically target the ER stress response for the treatment/outcome of a variety of diseases.

Objective 1 will reveal key regulators, interactors and mediators of the ER stress response, objective 2 will determine which specific ER-stress and UPR components are involved in the pathogenesis of specific diseases and thus identify new targets for drug discovery and objective 3 will utilize current knowledge as well as incorporating new findings to develop therapies and new diagnostic markers. These aims are addressed in dedicated TRAIN-ERS research work packages.

  1. Obtain a mechanistic and quantitative understanding of the ER stress response and its functional consequences
  2. Delineate the role of the ER stress response in governing the development/progression/treatment resistance of ER stress-associated diseases
  3. Develop ER stress-based therapies and diagnostic markers