Does the activation/inhibition of ER stress affect the release of tissue damage markers and inflammatory mediators in an in vivo model of Hemorrhagic/Traumatic shock? TRAINERS researchers meet with multidisciplinary LBI Trauma team to develop an experimental plan to address this key question.

Team (from left to right): Ingrid Miller (VetMed), Julia Jilge (LBI trauma), Andrea Muellebne (VetMed), Catharina Duvigneau (VetMed), Andrey Kozlov (LBI trauma), Soheyl Bahrami (LBI trauma), Mohammad Jafarmadar (LBI trauma); second row:  Andreia Luís (LBI trauma) and Claudia Keibl (LBI trauma).

Hemorrhagic/Traumatic shock (HTS) is a pathological condition associated with multiple organ failure causing high morbidity and mortality. HTS is characterized by circulatory failure followed by tissue hypoxia and abnormal production of pro-inflammatory cytokines. These pathophysiological conditions occuring in trauma-hemorrhage are considered as key elements that trigger ER stress and Unfolded Protein Response. However, the pathological impact of ER stress in the HTS mediating organ failure is still not known. Therefore, the major aim of our current project is to better understand the mechanisms underlying HTS mediated organ failure. This project is running under the Marie Skłodowska Curie Innovative Training Network “TRAIN-ERS” (H2020-MSCA-ETN -675448) at the Ludwig Boltzmann Institute for Experimental and Clinical Traumatology (LBI, Vienna, Austria). Recently, we have established the experimental model, selected doses of tested substances and developed the experimental protocol. Our multidisciplnary team includes not only LBI Trauma staff but also scientists from the University of Veterinary Medicine Vienna. Our next step is to examine the effects of the activation/inhibition of ER stress on the release of tissue damage markers and inflammatory mediators induced by HTS. These experiments will be performed in a Shock In vivo model established at LBI Trauma by Professor Bahrami et al.