About the Science
Endoplasmic Reticulum (ER) stress is now emerging as a common feature in the pathology of numerous diseases including cancer, neurodegenerative disorders, metabolic syndromes and inflammatory diseases, annually affecting millions of patients worldwide, and posing an enormous cost burden on the health sector.
ER stress is caused by impaired function of the ER and accumulation of unfolded proteins in this compartment which triggers a set of signalling pathways termed the unfolded protein response (UPR). The UPR is an adaptive response that aims to resolve the stress through a multi-pronged approach, however, when ER stress cannot be resolved, the UPR induces cell death.
The molecular mechanisms involved in transition of the UPR from a protective to a death response are incompletely understood, but are fundamental to developing strategies to limit or avoid the pathological consequences of ER stress. Therefore understanding the ER stress response has the potential to allow us to tackle many ER stress-associated diseases and it thus represents a potential therapeutic intervention point that can be exploited to develop novel therapies and new diagnostic and prognostic markers for a wide range of diseases.
About the Network
TRAIN-ERS researchers will seek to understand the Endoplasmic Reticulum Stress Response and exploit it for therapeutic purposes.
The network is composed of 11 beneficiary partners that will supervise the young researchers and are located in Ireland, France, UK, Belgium, Sweden, Spain, Germany, Israel and Austria. TRAIN-ERS also has 6 partner organisations that will provide training and the opportunity for clinical and industrial secondments.
About the Training
TRAIN-ERS has an excellent training programme for 14 early stage researchers (ESR’s) where each ESR will be provided with unrivalled opportunities to develop their scientific and transferable skills which will be further enhanced through workplace secondments.
The training program will develop ESR’s scientific expertise by carrying out cutting-edge research projects as well as developing a broad portfolio of transferable skills useful for many career paths. It will also equip the ESR’s with the skills they need to convert knowledge and ideas into innovative new products and services.